My end goal was to come up with a set of nice renders that mimic classic scientific illustrations. I have the skull of a juvenile male black-tailed deer that I dissected and cleaned up myself a while ago, and I began my process of re-constructing it as accurately as possible within ZBrush by taking photogrammetry of it. I then made a rough 3-D model through AgiSoft PhotoScan, imported the raw scan data into Zbrush, and sculpted to refine the data into a more accurate representation of my specimen.
I then had a nice sculpt of the skull, but it was only a solid mesh with superficial details. A model with the internal sinuses, braincase, and cranial sutures carved out would be far more valuable from a scientific or medical perspective. I found a series of CT scan images of a similar species that I used to create a rough starting point for subtractive, internal Boolean shapes, then sculpted them to more accurately depict my skull.